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Scaffold meaning in genetics5/30/2023 Teach mini-lessonsīreak down new concepts into bite-sized pieces that build on one another. Using the much-lauded concept the Zone of Proximal Development, teachers can guide, support, and encourage students as they help them develop problem-solving strategies that can be generalized to other situations. He theorized that children learn best when they interact with other people, particularly more knowledgeable people, who provide guidance and encouragement to master new skills. The strategy is based on the work of Russian psychologist Len Vygotsky, whose theories stress the fundamental role of social interaction in cognitive development. In other words, it’s a way for teachers to provide support while students master new concepts and skills. Scaffolding is a way to provide support for students by breaking down learning into manageable chunks as they progress toward stronger understanding and ultimately greater independence. If you’re an administrator, share these practices with your teachers, and look for them during classroom walk-throughs. If you’re a teacher, integrate these as best practices, and observe their impact. Luckily there are many strategies educators can use to help students, and among the most important is scaffolding.īelow you’ll learn more about scaffolding in education, including 18 effective ways to scaffold learning. Almost all students, particularly those with unique learning needs, have felt exactly this way in the classroom at one time or another. Without being told the purpose of the activity, specific expectations, or background information, it would be overwhelming and discouraging to say the least. 1992 4:463–471.Providing students with better instructional scaffolding is often a schoolwide objective, but how can school leaders and teachers put this big idea into practice? Imagine someone plopping a giant box of odds and ends in front of you and telling you to figure out what to do with them with no further instructions. Characterization of a plant scaffold attachment region in a DNA fragment that normalizes transgene expression in tobacco. Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair. Stein G.S., Zaidi S.K., Braastad C.D., Montecino M., van Wijnen A.J., Choi J.-Y., Stein J.L., Lian J.B., Javed A. Specificity and functional significance of DNA interaction with the nuclear matrix: new approaches to clarify the old questions. The nuclear matrix: three-dimensional architecture and protein composition. Chromatin loops are selectively anchored using scaffold/matrix-attachment regions. Published by Oxford University Press on behalf of Nucleic Acids Research. In order to facilitate user friendly browsing and retrieval of the data obtained in present study, a web interface, MARome (), has been developed. Therefore, these data will help toward better understanding of genome functioning and designing effective anti-viral therapeutics. S/MARs identified in present study and their subsequent analysis also suggests that these elements act as hotspots for integration of retroviruses. Along with co-ordinate (location) details of S/MARs, the dataset also revealed details of S/MAR features, namely, length, inter-SMAR length (the chromatin loop size), nucleotide repeats, motif abundance, chromosomal distribution and genomic context. Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. However, a comprehensive genome-wide map of human S/MARs is yet not available. Several attempts have been made toward identification of S/MARs in genomes of various organisms including human. Therefore, genome-wide understanding of these elements holds great therapeutic promise. These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to compartmentalize the chromatin into structural and functional domains.
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